Polymer-assisted compaction of dna
WebSupplementary figure 3: The agarose gel image of the amplified internal transcribed spacer- 2 (ITS-2) region of Candida albicans.L2 (Lane 2) and L3 (Lane 3) represent the amplified … WebPolycations are popular agents for nonviral delivery of DNA to mammalian cells. Adding hydrophobic, biodegradable, or cell-penetrating functions could help to improve their …
Polymer-assisted compaction of dna
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WebApr 13, 2024 · Liao et al. construct single-chain polymeric nanoparticles (SCPNs) via disulfide bonds and demonstrate that, by reshuffling the disulfide bond pairing, the SCPNs … WebJun 17, 2024 · We have developed a non-cationic transfection vector in the form of a bottlebrush polymer-antisense oligonucleotide (ASO) conjugate. Termed pacDNA (polymer-assisted compaction of DNA), these agents show improved biopharmaceutical characteristics and antisense potency in vivo while suppressing non-antisense side …
WebDNA Compaction Induced by a Cationic Polymer or Surfactant Impact Gene Expression and DNA Degradation Marie-Louise Ainalem1*¤a, Andrew Bartles1¤b, Joscha Muck2¤c, Rita … WebSep 6, 2011 · Indeed, the threshold of [PEG] for DNA compaction at 60 mg/ml in Figure 3a was different from the overlap concentration at 95 mg/ml in Figure 4b. In conclusion, we have demonstrated for the first time the kinetics of the structural transition due to DNA compaction from direct evidence of the observation of single DNA molecules.
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WebThe modified polymer beget chemical-free in-situ synthesis of monodispersed ... The rheological properties were studied with the Anton Paar Modular Compact Rheometer equipment (MCR 102 parallel ... non-histone nuclear protein that is tightly linked to the cell cycle and does not appear to be expressed during DNA repair processes and ...
WebFeb 2, 2012 · Introduction. Compaction or condensation of DNA, usually defined as the collapse of extended DNA chains into compact structures (such as rods, fibers, flexible … fix slow chromebookWebAug 1, 1997 · The cationic polymers bind to DNA in a stoichiometry that is nearly 1:1 in primary amines to DNA phosphates. The apparent binding of all cationic polymers to DNA … fix slow boot windows 11WebSpecial Issue Information. Dear Colleagues, This Special Issue aims to present original articles or reviews on recent advances in the physical and analytical science of thermal phenomena of polymers and polymer composites. Computational techniques will be considered when it they are linked to new or previously published experimental results. fix slow computer speedWebIn the presence of over-threshold concentrations of simple neutral polymers and salts, DNA undergoes a cooperative change in its solution structure. Sedimentation studies at low … fix slow computer computerWebAbstract. In the presence of over-threshold concentrations of simple neutral polymers and salts, DNA undergoes a cooperative change in its solution structure. Sedimentation … fix slow computer startup freeWebAbstract. A theory of compactization of DNA is proposed based on the notion of the compact DNA particle as a polymer globule. The specifics of the theory is that it regards … fix slow computer free softwareWebDec 1, 2016 · 1. Brief historical perspective. Despite more than four decades of study, DNA compaction still remains an intriguing and elusive subject. The first studies began in the early 1970s, employing essentially multications and polycations as condensing agents [1], [2].At the same time, Lerman [3] reported the collapse of DNA through the combined … fix slow close toilet seat